Those topographic features, with dimensions ranging from nanometers to micrometers, can be identified in single-layer graphene transferred onto various substrates.
Given the large number of pre-miRNA candidates that can be identified in single-genome approaches, even after applying several filters for precursor robustness and stability, a conventional structural clustering approach is unfeasible.
While we did not perform extensive validation of private candidate CNVs, the single-cell CNV analysis shows that germline CNVs, shared clonal CNVs, and private candidate CNVs as small as ~2 Mb can be identified in single-cell genomes with GenomePlex, confirming other reports that somatic CNVs are common in cultured cells (Abyzov et al., 2012).
Each of these five variants was identified in single individuals except for S192S, which was found in two individuals.
Spots for co-localization studies (Figures 1 and 2) were identified in single static images by circling with 8 pixel×8 pixel regions in MetaMorph (108 nm per pixel).
For the SLC10A2 gene only a few dysfunctional mutations were identified in single patients diagnosed with Crohn's disease, hypertriglyceridemia and/or in patients with different forms of bile acid malabsorption [28], [31], [35], [36].
Other single nucleotide polymorphisms (SNPs) were identified in single clones.
FANCG, PALB2 and SLX4 homozygous deletions are identified in single carcinomas while FANCM homozygous deletions are identified in 2 carcinomas.
DC were identified in single label immunohistological studies by size, morphology and staining with the appropriate marker.
