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This approach allows the comparison of large numbers of peptide species that may not be identified in normal data-dependent MS/MS studies for reasons that include poor peptide fragmentation, co-elution of highly abundant species and/or informatics limitations - presumably similar factors that leave a significant number of detected species in LC-MS/MS analyses unidentified.
Yet, actions of VEGF are beginning to be identified in normal organs of the adult, examples being the role of VEGF in function and survival of normal blood vessels, blood pressure regulation, and renal, neurological, and hepatic function (Horowitz et al, 1997; Eremina et al, 2003; DeLeve et al, 2004; Kamba et al, 2006; Lambrechts and Carmeliet, 2006).
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In contrast, no P450 was identified in normal stomach.
Subsequently, RAS protooncogenes were identified in normal cells.
These structures have not been identified in normal tissues.
In contrast with cancer cell lines, no CEA protein and mRNA were identified in normal cells.
No reactivity has been identified in normal tissues with the exception of fetal hepatocytes.
Two populations of Thy-1+ve cells were identified in normal skin.
No HPVs have been identified in normal breast tissues from normal women who have had cosmetic surgery.
Using electron microscopy, TJ structures were identified in normal breast as well as in breast tumour tissue.
Borderline expression of CCAT1 was identified in normal tissue obtained from patients with benign conditions [mean Relative Quantity (RQ) = 5.9].
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CEO of Professional Science Editing for Scientists @ prosciediting.com