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Decreasing costs of exome and genome sequencing and the growth of population- and clinic-based biobanks mean some clinically relevant genomic variants are likely to be identified in large numbers of research participants.
One or more large feeding hepatic arteries, small central and septal arteries, and early draining veins often can be identified in large lesions (Fig. 2B and C)[ 66, 68 70 ].
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The relatively broad clinical spectrum of KAT6B variants means that clinical diagnosis is not always easy and suggests that affected individuals might be identified in large-scale exome and genome sequencing programmes rather than as a result of targeted testing.
However, more informative single LINE-1 loci should be identified in larger studies before designing cost-effective clinical tests based on locus-specific LINE-1 methylation.
However, these factors were identified in large cohorts and do not always apply to individual patients.
A group of proteolytic enzymes (particularly trypsin; spots 28, 31, 32, 36 41) was identified in large amounts in all 2D gels of D. pulex.
Currently, >30 genetic variants have been identified in large multicenter studies with sufficient power to be associated with an increased risk of type 2 diabetes (1– 3).
Repetitive sequences are not only found in eukaryotic genomes [ 15], but have also been identified in large DNA viruses, where they are involved in genome replication and gene transcription [ 16, 17].
Since the first report on antiganglioside antibodies in GBS [ 70], it had been identified in large group of patients and its association had been established with different clinical subtypes of GBS.
Similarly, only 1 and 2 cases were identified in large population-based cohorts of 2004 and 1750 consecutive renal carcinomas, respectively, in institutions from Europe (Pilsen) and North America Calgaryy), which were screened by morphology.
No evidence has been identified in large scale pooled analyses of the worldwide data for a possible alternate explanation that sexually transmitted infections act as a co-factor in HPV persistence and/or progression.
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