One important function appears to be as members of chromatin complexes, for example, JARID1A is found associated to the PRC2 Polycomb complex, important in establishing repressive chromatin marks during development, and JARID1C can be identified in complexes with other repressive chromatin modulators such as HDAC1/2/REST, or the H3K9 methyltransferase G9a [ 77, 164].
In contrast, a number of mutations have been identified in complex IV assembly factors.
Forty-six different units have been identified in complex I from bovine heart mitochondria [ 31], although the 14 bacterial subunits are the minimum needed for sufficient energy transduction by complex I [ 32].
Six positively selected sites were identified in complex IV: 178 in subunit COX1, 54 and 187 in subunit COX2, and 55, 155, and 171 in subunit COX3 (Fig. 5a).
Actin was identified in complex with specific subunits of most ATPases, together with four nuclear Arps (4, 5, 6 and 8) in all organisms, with the exception of yeast.
GADD45 has also been identified in complexes with AID and TDG or AID and MBD4.
Components of the death receptor-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
Histologically, a distinct area of adipose tissue just overlaying the dura mater could be identified in cell scaffold complex treated group at 24 weeks post-operation.
Finally, the α subunit of the human COPI complex has been identified in a complex with PHB (http://bioinfow.dep.usal.es/apid/index.htm).htm
The box C/D snoRNP component fibrillarin responsible for the methyltransferase activity of the complex has been identified in AGO2 complexes and another box C/D snoRNP core protein, NOP56, in AGO1 complexes [50,51].
