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While it is clear that the UPS is an important cellular defence against toxic polyglutamine protein expression [34], it is less clear how its efficiency can be hindered by expression of mutant polyglutamine proteins.
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This merging can be hindered by among-sample variation of expression levels of individual genes and genetic backgrounds.
Additionally, broad application of traditional viral gene delivery can be hindered by limitations in the size of the expression cassette to be transferred, host immunity to repeat infections, and the possibility of insertional mutagenesis [10], [11].
Businesses can also be hindered by government cuts.
Sunday night's viewing is more likely to be hindered by cloud cover.
"When you're an actor, you can be hindered by your own narcissism.
Since the program is voluntary, however, eligibility could be hindered by investor and regulatory restrictions.
Moreover, grain boundary migration can be hindered by sluggish kinetics.
People tend to be hindered by it".
Your days will not be hindered by the fact that he is ignoring you.
Candidate vaccines to date have been hindered by low expression levels and the induction of non-neutralising antibodies.
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