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For example, the patient populations tend to be highly selected, and long-term outcome studies are notoriously difficult to perform and are often limited in duration because of cost.
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Furthermore, the surgical patients were highly selected, and this selection could bias the beneficial outcome.
Among the British, these alleles have evidently been highly selected and have spread rapidly.
The present reference material may, however, not be representative for the general headache population, as they are highly selected and characterised as having refractory or rare headache before they are referred.
It may be argued that methadone clients were highly selected, and that their profile of risk behaviours, and their geographic distribution may have been biased.
Thus, this population was highly selected and neither inflammation nor malnutrition was observed.
Participants in the earlier randomised clinical trials for CRC were highly selected and most patients were aged <70 years.
On the other hand, our study population was highly selected, and therefore our results may not be necessarily applicable to other populations.
For these groups are highly selected and they force a teacher continually to renew the fundamental principles of the sciences from which his specialty takes off.
In our study, patients were highly selected and represented less than one third of all patients undergoing CVVH in our unit.
Moreover, elderly patients enrolled in trials are highly selected, and generally fitter than the average patients observed in daily clinical practice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com