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The desmosomal cadherins and DSP show complex patterns of expression, and thus are likely to be highly regulated at the transcription level, although, little is known about this regulation (47, 69, 70).
Thus, the process of ubiquitination appears to be highly regulated at various levels of the UPS.
For example, central carbon metabolism is thought to be highly regulated at the post-transcriptional level [ 81].
It is also thought to be highly regulated at the mRNA level under different physiological conditions by both PPAR and HNF4 α [ 40].
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The RGS protein family is highly regulated at the transcriptional level and up-regulation of certain RGS proteins decreases immune cell migration and reduced chemokine-dependent calcium flux.
However, we believe that this does not undermine our main novel message, which is to highlight that transitions between the different cell stages of Capsaspora are highly regulated at the transcriptomic level and that this regulation has features in common with metazoans.
The L-tryptophan (Trp) biosynthesis pathway is highly regulated at multiple levels.
Under normal physiological conditions, ROS production is highly regulated, at least in part, by complex I [94 98].
Moreover, the modulation of AsA reduction by the modified white LED light treatment was highly regulated at the transcriptional level.
We found that all three Aurora B kinase homologues were highly regulated at the transcript level (1.8, 2.3 and 3-fold, respectively), as were other proteins found in the chromosomal passenger complex, in which TbAUK1 is found (Fig. 5C, red circles) [36].
In addition, while PGC-1β expression in distinct tissues is unaffected by physiological processes characterized by increased energy expenditure, such as cold exposure (in brown adipose tissue), fasting (in liver) or exercise (in muscle), PGC-1α is highly regulated at the transcriptional level under similar physiological challenges [15] [17].
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