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Both viruses were shown to be highly pathogenic for chickens (intravenous pathogenicity index 3).
Gochang1 virus has been shown to be highly pathogenic for chickens (intravenous pathogenicity index 3.0) (6 ).
(iii) Would such a virus be highly pathogenic for humans?
The rescued virus was also found to be highly pathogenic for mice by intradermal injection producing a fatal disease indistinguishable from that of wild-type virus.
Therefore, both novel influenza subtype H5N5 viruses were assumed to be highly pathogenic for chickens and moderately virulent for mice (5 ).
The next mosquito-borne flavivirus, which might be introduced to regions far from its original habitats, may be highly pathogenic for humans, farm animals, or pets, as many strains of JEV group are.
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Both H5N8 subtype isolates were highly pathogenic for chickens and showed moderate pathogenicity for mice.
The corresponding isolate, A/Turkey/Suzdalka/Nov-1/05, from turkey spleen was highly pathogenic for chickens in the laboratory intravenous pathogenicity index test.
The intravenous pathogenicity index of GD01/2014 was 3.0, which indicates that the isolate is highly pathogenic for chickens.
However, it is highly pathogenic for domestic poultry, causing significant mortality in chickens and turkeys.
Taken together, these data suggest that this virus is highly pathogenic for domestic rabbits and belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Simplexvirus.
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