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Biologic agents such as infliximab (IFX) have been shown to be highly efficacious in treating immune disorders such as inflammatory bowel disease and rheumatoid arthritis.
Pain modulators, such as tricyclics and selective serotonin reuptake inhibitors (SSRIs), have been shown to be highly efficacious in patients with noncardiac chest pain of presumed esophageal origin.86, 87, 88 These visceral analgesics are used in non mood-altering low doses, to relieve esophageal painon mood-altering
[6], [7] All three trials were stopped prematurely by their respective Data and Safety Monitoring Boards when, at interim analyses, circumcision was found to be highly efficacious in reducing HIV incidence, indicating that it would be unethical to continue withholding circumcision from the control group.
Halo traction, releases and osteotomies have proven to be highly efficacious in the treatment of severe and rigid idiopathic scoliosis.
Esculentin and temporin, two CAMPs that are candidates for drug development, were found to be highly efficacious in promoting C. elegans survival following infection by P. aeruginosa.
Metoclopramide, a central dopamine antagonist, has been most widely studied and proven to be highly efficacious in augmenting milk supply [ 8, 10- 14].
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Chen, Y. et al. Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models.
Hand hygiene and in particular hand rubbing using alcohol-based hand rub (ABHR) is highly efficacious in preventing HCAI transmission.
MRx0004 significantly reduced the total number of BALF cells compared to HDM alone (Fig. 1a,b) and was highly efficacious in alleviating the magnitude of the neutrophilic inflammatory response.
Live vaccines (LAIVs) are highly efficacious in children, but they are not used in HIV-infected children du e to limited information.
Although bypass surgery is highly efficacious in the short term, long-term outcomes are limited by relatively high failure rates as a result of intimal hyperplasia, which is a common feature of vein graft disease.
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Justyna Jupowicz-Kozak
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