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On logistical grounds, conducting spirometry among subjects who reside thousands of miles apart would be highly difficult, if not impossible.
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If you refuse, second referrals can be highly difficult to obtain.
He suggested it would be "highly difficult, as difficult or more difficult than the original production".
Achieving the above-described goals by EM is a highly difficult, if not impossible, task.
In summary, the degree of biological weapons proliferation is highly uncertain, difficult to detect, and difficult to quantify.
These factors are themselves likely to be highly correlated, however, making it difficult to see if they operate independently.
One ironic conclusion in the report is that if businesses and the general public were only a bit more vigilant, the story would be quite a different one: of all the attacks 96percentt were deemed to be "not highly difficult", and that 97percentt "were avoidable without the need for organizations to resort to difficult or expensive countermeasures".
Falling into a mill well can be extremely hazardous as the tendency is to become trapped under the glacier, making rescue highly difficult, if not impossible.
It's difficult to be highly motivated all of the time on your own.
His speeches can be highly entertaining, but it is sometimes difficult to know if he means what he says or has simply been carried away by his own oratory.
Wrangling the data is difficult, since formats can be highly divergent between companies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com