(ii) Burial of polar groups in the non-polar interior of a protein is highly destabilizing, and the degree of destabilization depends on the relative polarity of this group.
They are tightly controlled, as their activity is highly destabilizing and mutagenic to their resident genomes.
"If things go down that path, it would be highly destabilizing".
Position 50 is a highly promiscuous site in CDR2, conceivably Asn50 (Es305) is highly destabilizing since all other charged and neutral amino acids are observed among kappa light chains.
Since it has been shown in other organisms that pmt mutant strains can be highly sensitive to cell wall destabilizing drugs and drugs targeting protein synthesis, including those used in C. neoformans as dominant selectable markers (such as hygromycin B), we used the ADE2 and URA5 genes as selectable markers to perform these experiments.
Similarly, the folding and assembly of (d-Cit-Sal)4-CONH2 (compound 7) would be highly favorable, because it lacks the destabilizing electrostatic interactions between the charged Lys side chains.
It's highly entrepreneurial and highly stressful.
Stathmin (STMN1) is a ubiquitous microtubule (MT) destabilizing protein linked to cancer and cell health: Stathmin is highly over-expressed in leukemias and a number of other cancers, where its expression level often correlates with cancer stage progression and prognosis for survival [ 1- 3].
For this reason, the three destabilizing mutations L259S, R384G, and V280A are highly deleterious to Aichi/1968.
