The condition, although not fatal, is highly debilitating and well recorded.
In high doses, anticholinergics cause delirium, a fragmented and disjointed experience that is highly debilitating and often forgotten after it is over.
These diseases are highly debilitating, and are typically characterized by progressive neurodegeneration, seizures and shortened lifespan (Schon and Manfredi, 2003).
CHIKV produces epidemics of great magnitude, is highly debilitating, and does not have any specific treatment or vaccine.
Finally, although the preponderance of the behavioral, neuroimaging, and neuropathological evidence indicates that chronic Mn exposure does not cause degeneration of nigrostriatal dopamine neurons and PD, the parkinsonism and other neurological effects resulting from chronic Mn exposure are highly debilitating, and it should not be treated with any less importance.
Bipolar disorder and substance use disorders are highly debilitating conditions, and especially when co-occurring, are associated with a variety of negative outcomes.
Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical need for regenerative therapies apparent.
In researching the issue, he saw that many of these suicides were directly related to Post Traumatic Stress Disorder (PTSD) or Traumatic Brain Injury (TBI) -- serious combat-related conditions that, while being highly debilitating, are less visible than other physical injuries, leading to a great sense of isolation among those living with them.
