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In a variety of systems and organisms, MELK appears to be highly conserved with a significant effect on proliferation, cell cycle regulation, and apoptosis.
We have sequenced the sex-related locus in eleven different E. cuniculi isolates, however, and found them to be highly conserved with the exception of a few point mutations, which tellingly are restricted to the flanking genes and are not found in the HMG or weak HMG genes (Figures 3 and 4).
All Oct4-associated proteins were found to be highly conserved, with a median sequence identity of 94%, compared to 77% genomic median.
The 16S rRNA gene requires a nucleotide model of evolution and hence has an incomparable value; it is well known to be highly conserved, with variable regions.
Interestingly, we found 357 ESRTs to be highly conserved, with orthologs in higher eukaryotes such as human (Additional file 3: Table S3 p3).
We show KIR3DL0 to be highly conserved with the identification of orthologues in human (Homo sapiens), common chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), rhesus monkey (Macaca mulatta) and common marmoset (Callithrix jacchus).
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hHFM1 encodes multiple conserved DNA/RNA helicase sequence motifs, is highly conserved with the Saccharomyces cerevisiae gene Mer3, a known helicase, and is preferentially expressed in germline tissues [51].
Overall, PvMSP4 is highly conserved with only eight amino acid substitutions.
Deduced amino-acid sequences from seven BAC clones were highly conserved with the rice, maize, and sorghum lax-barrenstalk1orthogenes.
But in contrast STR regions/loci used in clinical analysis are linked to genes that are highly conserved with an unknown amount of variability.
In fact, both proteins are highly conserved, with 75% similarity across their entire length and 63% homology at the amino-acid level (Iyer et al., 2004; Shiama, 1997).
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