Sentence examples for be highly bound by from inspiring English sources
The fourth compound, PFOS, was found to be highly bound by both albumin and β-lipoproteins".
A similar phenomenon was reported for Caenorhabditis elegans and Drosophila, with certain regions being highly bound by many different transcription factors [so-called highly occupied target ("HOT") regions] (Moorman et al. 2006 ; Gerstein et al. 2010 ; Roy et al. 2010 ).
For example, a region overlapping two mesodermal CRMs upstream of tribbles (trbl), an FC-specific gene, is highly bound by Ttk69 (Fig. 4F), whereas there is no significant Lmd binding.
The functional enrichment analysis of the genes determined to be more highly bound by AHR when cells were treated with TCDD or BaP than when they were in the naive state identified the KEGG pathway "metabolism of xenobiotics by cyto-chrome P450" as enriched when cells were exposed to either ligand (BaP, p = 0.00056; TCDD, p = 0.039).
A case in point in this context may be the tumor suppressor gene Pten, which we verified by QPCR as being more highly bound by AHR in naive cells than in BaP- or TCDD-treated cells.
In separate studies, evacetrapib was found to be highly protein bound (>99%) and metabolized primarily by oxidative pathways.
Furthermore, H3K36me3 levels were high in genic regions directly downstream of the TSS of genes that were highly expressed and bound by EWS-FLI1, whereas the repressive histone marks H3K9me3 and H3K27me3 were depleted in the promoters of these genes.
SRC is known to be highly regulated by and to bind to the RACK1 [21].
26 It is highly protein bound (>98.8%) 24 and is metabolized by cytochrome P450 (CYP) 3A4, and to a lesser degree by CYP1A2 and CYP2C8.
