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Tumors containing amplifications of genes encoding Notch signaling components (e.g. Notch and Jagged) tend to be highly aggressive and metastatic.
These findings are unexpected, given that MCC is generally considered to be highly aggressive and lethal, and mortality would be expected to reflect incidence.
G388R sustains the activation of FGFR4 [ 125], and human cancers characterized by this SNP were reported to be highly aggressive and metastatic in nature [ 124, 126– 126].
MCC is considered to be highly aggressive and lethal [ 1, 2]; in fact, more than half of the persons with non-localized MCC die within 1 year of diagnosis [ 11].
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There are some tumors, though small when discovered, that are highly aggressive and may spread despite early discovery.
The British press is highly aggressive and competitive, with 13 national dailies selling a startling 14 million copies.
In one striking use of the method, reported online Sunday in Nature Biotechnology, mice were implanted with a human uterine tumor that was highly aggressive and resistant to many drugs.
These are highly aggressive and infiltrative tumours, may present with distant metastases and demonstrate high recurrence rate.
Neuroblastomas are highly aggressive and readily metastasising tumours of neuroectodermal origin with a median age at diagnosis of 22 months [30].
Being conscientious of financial hardship for many Americans, Virgin Mobile USA unveiled new rate plans today that are highly aggressive and easy on the wallet.
Males are highly aggressive and exhibit sexual competition over the smaller females.
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