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The distributions for different activities are linked, since we have shown that P450s with good activity on one substrate will frequently also be highly active on chemically similar substrates (similar linkages have been observed in proteins created by recombination [ 45, 46]).
However, it has been shown that many exciting products found to be highly active on the level of the fungal cell (in vitro activity) were either excessively toxic or inactive when tested in vivo[ 10].
The compound 10 was found to be highly active on SK-MEL-5 (melanoma) with cell promotion of −86.52% followed by UACC-62 (melanoma) with cell promotion of −84.39% and COLO 205 (colon cancer) with cell promotion of −84.05% while the maximum cell promotion was observed on UACC-257 (melanoma), which showed 16.03% growth promotion (83.97% growth inhibition) at one-dose assay.
Compound 13 was found to be highly active on HT29 (colon cancer) with cell promotion of −76.24% followed by 786-0 A498A498 (renal cancer) with cell promotion of −58.93% and −56.92%, respectively, while the maximum cell promotion was observed on NCI/ADR-RES (ovarian cancer), which showed 39.32% growth promotion (12.87% growth inhibition) at one-dose assay.
Compound 5 was found to be highly active on COLO 205 (colon cancer) with cell promotion of −59.43% followed by RXF 393 (renal cancer) with cell promotion of −57.61% and SF-295 (CNS cancer) with cell promotion of −55.32% while the maximum cell promotion was observed on TK-10 (renal cancer), which showed 24.04% growth promotion (75.96% growth inhibition) at one-dose assay.
Compound 12 was found to be highly active on HT29 (colon cancer) with cell promotion of −6.41% followed by MDA-MB-468 (breast cancer) with cell promotion of −6.34% and CCRF-CEM (leukemia) with cell promotion of −16.72% while the maximum cell promotion was observed on TK-10 (renal cancer), which showed 102.74% growth promotion at one-dose assay.
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"Gaullist networks are highly active on his behalf and he has the support of other astonishing and unexpected people".
In this critical environment, the petrol, gas and electricity firms, many of which are highly active on the wholesale commodity markets, are acutely vulnerable to reputational damage should an inquiry conclude they have been rigging the system.
The resulting inhibitors were highly active on both PDE4B1 and PDE4D2 and underwent rapid degradation in human plasma by paraoxonase 1.
Scorpion α-toxins vary greatly in preference for sodium channels of insects and mammals, and some of them are highly active on insects.
Each was kept in a cool room (61 degrees Fahrenheit) for two hours and then given a PET scan, which lights up any tissue that is using a lot of glucose, showing that it is highly active on a metabolic level.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com