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Tagliazucchi's study adds to this growing body of research which suggests that psychedelic substances could be given safely in combination to improve treatment and to make psychotherapy more beneficial.
This study illustrates that prolonged subcutaneous IL-2 can be given safely in the outpatient setting.
Our data suggest that docetaxel capecitabine at both dose levels investigated can be given safely in an ambulatory setting without unexpected toxicity.
In phase I and II combination trials, SU5416 could be given safely in combination with 5-FU and leucovorin, but combining SU5416 with cisplatinum and gemcitabine yielded an unexpectedly high number of severe thromboembolic complications, leading to premature closing of the study (Kuenen et al, 2002a).
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Patients with BM were excluded from these pivotal trials, however, subsequently initiated smaller studies also investigated the outcome of BM-patients and several authors have shown that sunitinib and sorafenib can be given safely, i.e. without haemorrhage in patients with BMs [ 6, 14- 18].
SRL172 can be given safely into tumour deposits and the pleural cavity in patients with malignant mesothelioma and we have established the dose for phase II testing.
O negative is an a key blood type because it can be given safely to patients in other blood groups.
However, experience with paclitaxel carboplatin has shown that the two agents can be given safely without reduction in the dosage of either component (Kaye, 2000; du Bois et al, 2003).
Zosuquidar has significantly lower affinity for CYP3A than for P-gp [ 13] and phase I trials have shown that zosuquidar can be given safely to the AML patients in combination with daunorubicin and cytarabine [ 14, 15].
In addition, carboplatin can be given safely to most patients, particularly those with moderate renal insufficiency.
In this study, we demonstrated that valspodar can be given safely with acceptable toxicity at PEG-LD 25 mg m−2 every 2 weeks.
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