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Based on the theory that large patients have a higher elimination capacity, it is assumed that those patients need to be given higher doses than smaller patients to reach equal drug concentrations.
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During the final stages he had to be given high doses of morphine, as he felt continually as if he was drowning.
Patients were not told that they could be given high doses of the fluids or that they faced a risk of serious bleeding, according to a copy of the consent form obtained by the Investigative Fund.
Conclusions: Data trends suggested that gender stereotypes about how patients managed pain played a role in dose intensity decisions because female patients on average were given higher doses of pain medication than male patients were by all the nurses in the study.
A 2010 study found that between 1997 and 2005, women were more likely to be prescribed opioids and were given higher doses for longer periods of time.
Yet, he notes that the rats were given higher doses of ecstasy than would be seen in humans, so the results may not translate directly to people.
In contrast, patients sedated with dexmedetomidine or benzodiazepines were given higher doses under the BIS-augmented dexmedetomidine [0.46 mcg/kg/h vs. 0.33 mcg/kg/h; p<0.0001], lorazepam [4.13 mg/h vs. 3.29 mg/h p<0.0001], and midazolam [3.73 mg/h vs 2.86 mg/h; p<0.0001]) protocol compared to clinical assessment alone.
As safety did not show a dose response relation, it is suggested that IBD patients with an increase in CRP and Hb <9 g/dl are given higher doses of >1,000 mg IV iron isomaltoside 1,000.
The question of a paradoxical effect has been raised for the echinocandins, although the more likely explanation is that sicker patients or patients who were not responding well to therapy were given higher doses.
Sometimes people have been given higher doses because people complain of the problem worsening, when in fact the medicine was causing their problems to worsen.
This may have introduced bias because patients with more severe ABD may have been more likely to be given high dose sedation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com