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Paliperidone is recommended to be given at lower doses in patients with renal impairment.
Combining different weight loss agents with different mechanisms of action is appealing for two reasons: first, it is less likely to be hindered by redundancy and compensation in appetite regulatory pathways; and second, it enables each component to be given at lower dose to reduce side effects.
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A recent study from Cadet et al [22] demonstrated a preconditioning protective effect of METH on subsequent METH binge exposure if the pretreatment of METH was given at lower doses over a longer period of time.
However, steatosis was not observed when INH was given at lower doses for longer periods of time to either mice or rats.
In the clinical outpatient setting in Denmark, quetiapine XR was significantly more likely than IR to be used in higher antipsychotic dosages in patients diagnosed with schizophrenia spectrum disorder, whereas quetiapine IR was given at lower doses and more often 'as needed' to treat anxiety or psychoses.
Although the prevalence of clinically relevant valvular heart disease did not appear increased when cabergoline is given at lower doses to patients with prolactinomas, such long-term use has also been associated with valvular fibrotic changes (Kars et al., 2008; Martin et al., 2009).
For patients with dose-limiting haematological toxicity in whom further treatment cycles were deemed appropriate these were to be given at the lower previous dose level.
Since prescription of intravenous fluid therapy given at full maintenance rate may be potentially dangerous when renal water excretion is limited by ADH excess, parenteral fluid therapy will be given at a lower rate than the recommended average maintenance rate [ 8].
A combination treatment that would allow the drug to be given at a much lower dose could make chemotherapy easier on patients.
Calcium acetate has about twice the phosphate-binding capacity of calcium carbonate, expressed per milligram of elemental calcium, and can be given at a somewhat lower dose.
For patients who had stable disease after one cycle, but during that cycle experienced a DLT, subsequent protocol therapy could be given at one dose level lower than their assigned starting dose, and further dose reductions could be made.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com