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The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits.The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping.
HPV DNA-positive samples will be genotyped using a commercial kit in the four microbiology laboratories.
Given that these candidate SNPs passed the A/T-G/C exclusion, each could be genotyped using a single probe.
The Kaiser Permanente and University of California, San Francisco (UCSF) collaboration [ 8] has obtained detailed phenotyped and genotyped data for over 100,000 people, and earlier this year, it was announced that the UK Biobank sample of 500,000 people will be genotyped using a single-nucleotide polymorphism (SNP) array [ 9].
Each animal in an outbreeding population is genetically unique and must be genotyped using a high-density marker set; regression models for mapping must accommodate multiple founder alleles, and complex breeding designs give rise to polygenic covariance among related animals that must be accounted for in mapping analysis.
In the interest of cost efficiency, it is likely that selection candidates will not be genotyped using a high-density array such as the PorcineSNP60 but rather will be genotyped on a low-density array like the recently released GeneSeek Genomic Profiler for Porcine LD (GGP-Porcine: GeneSeek Inc., a Neogen Co., Lincoln, NE), a subset of the PorcineSNP60 containing roughly 10K SNP.
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Second, what is the number of SNPs that can be genotyped using an Infinium II assay?
The snails were genotyped using a set of RAD-seq-derived loci that flank the supergene, and instances of recombination tested by comparing inferred supergene genotype against RAD-marker genotype.
2628 Atlantic salmon smolts, which had been experimentally infested with C. rogercresseyi, were genotyped using a 50K SNP array.
A total of 502 isolates of Mycobacterium tuberculosis collected in Taiwan were genotyped using a modified and high-throughput typing system involving mycobacterial interspersed repetitive units.
DNA samples were genotyped using a panel of seven polymorphic markers spanning 30 cM and containing the HPCX candidate region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com