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Using this kind of analysis, hypotheses about on-target as well as off-target effects can be generated, that reflect the drug action in the population and under everyday life conditions.
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To identify gene modules, a topological overlap matrix [ 37] was generated that reflected connectivity scores and sorted genes based on an agglomerative hierarchical clustering algorithm (see Methods).
To query our gene expression data for transcriptional events associated with specific pathologic features of the Scnn1b-Tg model, customized gene lists were generated that reflected genes hypothesized or known to be involved in the pathogenesis of muco-obstructive lung diseases (Additional file 4: Results file S2 and Additional file 5: Results file S3).
For each of the three markers, a factor was generated that reflects the reciprocal percentage of cells that stained positive in such areas averaged over these five adenomas.
Features have to be generated that robustly reflect the complexity of the individual volumes, but cannot be overly complex or redundant.
A key strength of this instrument is that items were generated to reflect themes identified during in-depth interviews with people experiencing acute and chronic back pain.
Items were generated to reflect each of the 35 concepts.
Internationally, a momentum around social protection has been generated, as is reflected in the many countries that have recognized its critical importance for inclusive growth, equity, and resilience.
Proteome signatures that reflect modification by aHNE, aONE, both, or neither could be generated.
A total score was generated so that higher scores reflected more impairment, this scale had an α Cronbach of 0.54; vii) ; and viii).
A total score was generated so that higher scores reflected a more negative coping style, the α-Cronbach of this scale in this study was 0.93; vi) Self report on HIV status.
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