BMN precursors are generated in specific rhombomeres, which subsequently migrate towards their final destination at characteristic dorsolateral and rostrocaudal positions within the developing hindbrain.
To explain the mechanism how seizures are generated in specific brain areas or different brain structures, various studies have been performed worldwide involving behavioral, electrophysiological, and molecular analysis [ 3– 6].
In 2006, Schirrmacher et al. convincingly demonstrated that [F]SiFA building blocks could be generated in high RCYs and specific activity (SA) by means of a IE from the corresponding- and chemically identical-F-precusors [ 5].
The rationale of this method is that the longer the telomeres are in each sample, the more PCR product will be generated in PCR reactions using primers specific for the telomeric DNA.
Consistent with the report that several components of the Ras/MAPK pathway are present in the expression profile of CD24− cancer cells [28], this observation suggested that cancer stem cells could be generated in response to the activation of specific signal transduction pathways.
The fact that this linear dsDNA species can be generated in control cells indicates that site-specific stalling at the replication origins is a common occurrence in normal human cells, as reported previously for mouse cells (29).
Though I feel permanently connected to a finished story in countless ways, there's always a sort of immediate recognition that the piece was generated in a specific time and a specific place and could never have been written by me, as it was, at any other time — not in the past, or the future.
However, the proof of efficacy was generated in a specific subgroup, namely migraine patients who responded poorly to sumatriptan, and therefore cannot be concluded for the general population without further investigation.
The individual code of transcription factors expressed in each region of VZ defines the fate of the neurons that are generated in that specific region [32].
However, given the temporal order of activation, we assume that the early part of the transient 40-Hz oscillations observed in our study is generated in the specific thalamocortical loop.
