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The hope is that working islets could be generated from human embryonic cells and implanted in patients with Type 1 diabetes, which would make insulin injections unnecessary.
Second, replacement tissues could be generated from human embryonic cells by driving them down the appropriate lineages with cytokines and other agents.
But if fully functional, islet-like structures could be generated from human embryonic stem cells, supply would not be a problem.
Retinal pigmented epithelium (RPE) and neural retina can be generated from human embryonic stem cells/induced pluripotent stem cells (hESCs/hiPSCs).
However, if muscle tissue is unavailable, myogenic cells can be generated from human induced pluripotent stem cells (hiPSCs) preferably without genetic engineering.
Heart-like cells can be generated from human skin cells by using small molecules and without genetic manipulation.
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iPS cells were generated from human adipose-derived mesenchymal stem cells as described previously64.
This mesenchymal cell line was generated from human MSCs overexpressing human telomerase reverse transcriptase to facilitate immortalization.
Because motor neurons cannot be removed from human subjects, they had been generated from human embryonic stem cells in the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, also at CUMC.
Neuronal cells expressing pro-opiomelanocortin (POMC), neuropeptide-Y/agouti-related protein (NPY/AgRP) were generated from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) obtained from patients with monogenic forms of obesity.
In this study, ectodermal precursor cells (EPCs) with the capacity to cross talk with hair-inductive dermal cells were generated from human induced pluripotent stem cells (hiPSCs) and assessed for HF-forming ability in vivo.
More suggestions(16)
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