However, species encompassing the T40 N-terminus and terminating after Tyr20 may have been generated by distinct cleavage events.
Additionally, each class is generated by distinct progenitor cell populations and is defined by differential transcription factor expression [ 7, 8]; for example, Hb9 distinguishes somatomotor from branchiomotor neurons.
It is well described that the solitary 9+0 primary cilia and multiple 9+2 cilia are generated by distinct cellular mechanisms from each other.
Generally, this is brain region specific and TP goes back to baseline in the AOB and MOB but not in the other regions, which is another point showing that they are generated by distinct sources of theta rhythmicity.
Nonetheless, previous study has found that neuronal oscillations are distributed linearly on the natural logarithmic scale and independent frequency bands which are generated by distinct oscillators with specific properties and physiological functions [ 18, 19].
The finding that associations of RBP and albumin with U-Cd are abolished in subjects with respectively glomerular and tubular impairment suggests that these associations are generated by distinct co-excretion mechanisms.
The different classes of small RNAs are generated by distinct, sometimes converging pathways involving, among others, several DICER-LIKE proteins for processing double stranded RNA and several ARGONAUTE proteins for incorporating small RNAs into RNA induced silencing complexes (RISC) or RNA induced transcriptional silencing (RITS) complexes [ 2].
The soluble IL-6R can be generated by two distinct mechanisms, namely, by proteolytic cleavage of the membrane receptor or by translation of a differentially spliced mRNA (Rose-John and Heinrich, 1994).
Alternatively, larger deletions can be generated by inducing two distinct DSBs, which can be repaired using an ssDNA donor harboring homology ends to DNA sequences flanking the distal sides of each cut (Cong et al., 2013; Ran et al., 2013a).
If some exons are omitted, or if the order of splicing changes, then several distinct messages can be generated by each gene.
