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When used with ambulatory children, BoNT-A is considered to be generally safe with relatively few and minor complications [ 19].
The treatments used in our study appeared to be generally safe, with no grade 4 toxicities observed and only few grade 3 toxicities occurring exclusively among patients treated with RE.
Randomized, clinical trials with open-label extensions (up to 3years) have demonstrated exenatide twice daily to be generally safe, with mild-to-moderate nausea reported as the most common side effect [15].
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New Zealand's mine sector is generally safe with 181 people killed in the past 114 years.
They observed that medical male circumcision is generally safe with few studies reporting adverse events after the procedure.
In conclusion, healthy house cats are generally safe with regard to excretion of Salmonella in the environment.
Using nationwide register based data we showed that both medical and surgical abortions are generally safe, with few serious complications when gestation is less than 63 days.
The cumulative safety data across many trials show that agents that inhibit CTLA-4 are generally safe, with unique, but usually manageable, side effects that are linked to their mechanism of stimulating immune responses.
Each study found the combination of methotrexate and etanercept to be generally safe and well-tolerated with no statistically significant increased rates and types of adverse events compared to the monotherapy groups.
Intramuscular olanzapine 10 mg was shown to be generally safe and tolerable in acutely agitated patients with schizophrenia.
Whilst it is important to exclude patients with severe renal and/or hepatic insufficiency, Ala-Gln supplementation is generally safe in patients with brain damage, lung damage with adequate technical support, gastrointestinal failure with recompensated circulatory shock, and resolved metabolic acidosis as well as normal substrate utilization.
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