On the other hand, P-type ATPases are the general targets of many drugs [ 18, 29].
The decoy hyper binding site strategy should be general for targeting overexpression of any double-stranded DNA-binding oncogenic transcription factor responsible for cancer cell proliferation.
Since it is known that guanylate cyclase is a general target of NO in many cell systems, some investigators have suggested that NO exerts its effects via cyclic guanosine 3',5'-monophosphate (cGMP) in both rat and rabbit parietal cells [ 13, 15].
It might be argued that reduced variation could beget a narrow distribution (e.g. characterized by abnormal kurtosis), non-representative of the normal population, which is the general target of behavioral neuroscience studies.
Actinomycin D and α-amanitin are general inhibitors of transcription, whereas flavopiridol targets the same step of transcription as DRB and is shown to inhibit transcription in vivo [39].
There are many different varieties and methods of attacks, they can generally all be grouped into several categories: by the general target of the attack, i.e., application, network, or mixed; by whether the attack is active or passive; by how the attack works, i.e., via password cracking or by exploiting code and cryptographic algorithms.
And while Mr. Santorum's cultural positions are likely to be targets of opportunity during a general election, it's not clear that they are during a Republican primary.
By contrast, the results of the ACCORD study (22) seem to indicate that less stringent goals than the general target of <7% may be more appropriate in patients treated with such hypoglycemic agents as sulfonylureas and/or insulin that are at risk of producing severe hypoglycemic events.
The hypotheses, in turn, are general statements about the target system of the scientific study, e.g., expressing some general fact about all individuals in the population.
