Decreasing fertility and increasing mortality are general hallmarks of aging that are typically accompanied by a declining activity level, altered metabolic rate, and a higher susceptibility to predation, parasites and disease.
High expression of HOXA9, HOXA10, and MEIS1 is considered to be a general hallmark of all MLL-FP leukemias, but a detailed analysis of patient expression data show that many t(4 11) leukemias do not express high levels of these genes (Stam et al., 2010; Trentin et al., 2009), indicating that other additional targets are likely to have an important role in t(4 11) leukemogenesis.
Age-related decline in immune function, or immunosenescence, appears to be a general hallmark of aging in multicellular organisms.
In fact, the multinucleated 'giant' cell formation and polyploid cell death could be a general hallmark of cancer, as well as a cellular response to various genotoxic stimuli such as UVA exposure, ionising radiation, and chemotherapy, and often associated with mutant p53.
Angiogenesis is a general hallmark of cancer; therefore, the inhibition of tumor-derived angiogenesis is considered to be an attractive target in the development of anti-cancer agents.
Moreover, alteration in normal growth factor responsiveness is a general hallmark of tumorigenesis in numerous cell types.
The DMRs were analyzed according to general hallmarks of their genomic localization.
Hospitalization was not a general hallmark of clinical severity, as the clinical management of patients changed during the study period, in compliance with the modifications in the National policy of pandemic influenza management.
A general hallmark of vagueness is that it involves borderline cases: possible cases that are neither clearly in the extension of the vague term nor clearly not in its extension.
Another general hallmark of viruses is that they can compensate for their small proteomes by the ability to interact with numerous cellular proteins.
