In particular for GR, important insight was gained from experiments in yeast, that characterised FKBP52 as stimulatory GR cofactor, while FKBP51 had no effect [18].
Early insights were gained from experiments using genetically engineered mammalian models and from studies manipulating HIF pharmacologically in humans.
Direct evidence that the intrinsic radiosensitivity of tumour cells is an important determinant of patient response to radiotherapy has been gained from experiments using a soft agar clonogenic assay (West, 1995, 1997).
Additional evidence for the role of Arg175 was gained from experiments with 1,2-cyclohexanedione (1,2-CHD) that (reportedly) specifically and reversibly modifies arginyl residues (Patthy and Smith 1975 a, b ).
Further knowledge could be gained from animal experiments by assessing complete follow-ups until the end of the growth period.
The present paper is aimed at extending the information about adhesive bonds that can be gained from these experiments, by evaluating also the adhesion force as a function of elongation.
Several important insights can be gained from these experiments.
Second, mechanistic and temporal details governing the emergence of escape mutations will certainly be gained from in vitro experiments, including the characterization of single colonies over time.
Such insights into potential cellular mechanisms cannot easily be gained from in vivo experiments where cellular effects can typically only be assessed at endpoint, thus highlighting the value of this mathematical model.
We thus believe that the data that could be gained from such an experiment would not be very believable.
