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In this case, we left the original item parameters unchanged, because they are already in use, and there is little to be gained by replacing those parameters.
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But if there are no such things, what is gained by replacing Platonic Forms with Stoic concepts, by replacing one fiction with another?
Nothing could be gained by an inquest.
Experience will be gained by practicing constantly.
Experience points are gained by completing quests.
Research is gained by building mage towers.
Irreplaceability is the feature that what is lost in choosing one alternative over another cannot be replaced by what is gained in choosing another alternative.
The aim was to reap huge efficiency gains by replacing nearly all of America's ageing tactical aircraft (the air force's F-16s and A-10s; the navy's A/F-18s and the marines' AV8B jump jets) with three variants of one basic design.
The empirical P-value of Tloss(X) is computed by replacing 'gain' with 'loss' and reversing the inequality in Step 4. Both definitions yield P-values that are easy to interpret and are automatically adjusted for multiple comparisons across the markers.
In this argument, gene B could be replaced by a function gained by resistance that is difficult to be targeted directly, such as transporter MRP1 in the case of cancer, or any other cellular function that distinguishes the target cells from "normal" cells.
"When I have the CEO of a large oil company and drilling company saying they would follow the same sequence of events, that tells me there isn't anything to gain by [by replacing BP with them]," Allen said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com