The psychosocial functioning scale utilised in the current study needs to be further validated in future research, as only internal reliability and internal validity was assessed.
Candidate biomarkers should be further validated in controlled human studies.
This approach demonstrates that D. discoideum is a suitable surrogate host for preliminary high-throughput screening of antivirulence agents and that PPK1 is a suitable target for developing novel antivirulence compounds that can be further validated in mammalian models.
The algorithm should also be further validated in lager datasets for different ICUs.
These results need to be further validated in larger multicentre prospective studies.
As such, these biomarker data need to be further validated in larger multicentre prospective studies.
Despite promising initial forecasts for the UK and Denmark, as well as for Italy, Spain, West Germany (Bohk and Rau 2014), and the USA (Bohk and Rau 2016), our model will be further validated in a next step.
The addition of posttreatment PET/CT to serum CA-125 may be valuable in risk stratification of the subset of patients with negative CA-125, which may be further validated in a larger cohort.
Our theoretical framework should be further validated in the context of clinical studies.
These data will be further validated in a large prospective RA study presently being evaluated.
Although our two-gene signature is examined in two independent cohort groups, robustness of signature should be further validated in larger cohort.
