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Then based upon the p-values obtained from SAM[33] and a visual inspection of genes for genes that were more overly expressed than the others, a top group of 58 genes was chosen to be further validated for their influence on lifespan[32].
No matter what regulatory mechanisms, the identification of 4 transcripts of chaperone genes as biomarker for viability needs to be further validated for a wide range of environmental conditions to determine the lethal conditions for which they are bona fide.
However, due to the lack of patient survival and outcome data in the current study, these molecules need to be further validated for their value as biomarkers in larger clinical trials.
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Partial least squares regression was applied to derive QSAR models, which were further validated for statistical significance by internal and external validation.
The CoMFA and CoMSIA models have been further validated for their stability and robustness using group validation and bootstrapping techniques and for their predictive abilities using an external test set of ten compounds.
Partial Least Squares Regression (PLSR) method coupled was applied to derive QSAR models which were further validated for statistical significance and predictive ability by internal and external validation.
stepwise (SW), genetic algorithm (GA) and simulated annealing (SA) were applied to derive QSAR models which were further validated for statistical significance and predictive ability by internal and external validation.
The partial least square (PLS) regression method and kNN-MFA methodology coupled with feature selection methods viz., stepwise (SW) and simulated annealing (SA) were applied to derive QSAR models which were further validated for statistical significance and predictive ability by internal and external validation.
The studies were performed by the partial least squares method coupled with various feature selection methods, such as genetic algorithm (GA) and stepwise methods, to derive QSAR models, which were further validated for statistical significance and predictive ability by internal and external validation.
The MAPS was further validated for prognostic significance in 84 lung adenocarcinoma patients from an independent database.
This model is further validated for a range of injection pressures for Spray A flames.
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