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The increase in the expression level of ERα (Esr1) could partly explain the genistein sensitivity on day 10 observed here (Figure S8), but it remains to be further elucidated whether nuclear receptors such as ERα and/or ERβ are involved in alteration of DNA methylation levels in genistein-mediated DMRs.
It remains to be further elucidated whether Mfn1, Mfn2, Mff and Fis1 are involved in regulating cardiotoxicity.
It is remains to be further elucidated whether ARC is involved in the maintenance of mitochondrial homeostasis under these pathological conditions.
However, it needs to be further elucidated, whether the COX-2 levels in colorectal adenomas are elevated compared to normal mucosa.
It remains to be further elucidated whether MBCT as an adjunctive therapy to CBT with ERP might be useful to address some of the challenges mentioned above.
It remains to be further elucidated whether, and through what mechanisms, the increased ability to form contacts functionally contributes to anchorage-independent growth or other tumorigenesis-associated phenotypes in each of these instances.
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Studies of the patterns of sequence and functional divergence between human paralogs can be further elucidated by future investigations into whether, and the extent to which, structural resemblance between paralogs impinges on the evolution of novel function.
Since the cadmium concentration in farming lands is still increasing, the present study was undertaken to further elucidate whether the cadmium concentration in the kidney is still increasing.
Based on the approaches and studies described here, it will be possible to further elucidate whether highly HOCs with log KOW values > 5 bioconcentrate less than what may be expected from their hydrophobicity.
Therefore, it is essential to further elucidate whether kidney-specific knockout of BHD in the mouse is also implicated in kidney tumorigenesis, and what mechanism is involved.
To further elucidate whether PKC was responsible for the phosphorylation of Nav1.8, in vitro PKC kinase assays were performed to detect the phosphorylated Nav1.8.
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