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It is also involved in the degradation of angiotensin I to form (des-Asp) Angiotensin I, which can be further cleavage to angiotensin III [ 21].
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However, these predictions could be further improved by integrating proteasome cleavage (in conjugation with transporter associated with antigen processing (TAP) binding) prediction, as well as T cell receptor binding prediction.
Glycine can be further degraded via a glycine cleavage system.
As described for the cleavage product of LRR-RLK, these cleavage products may be further degraded after silencing by the corresponding miRNAs [ 34].
The principle of using a detecting antibody to a substrate sequence buried within the native substrates alpha-helix may be further expanded to other specific enzyme cleavage reactions in the future.
However, only one cleavage site could be further validated by 5' RACE in Glyma13640 and Glyma6g09100.
Additionally, the cleavage products may be further degraded by other degradation systems notably via N-terminal destabilizing residues which may make the target more susceptible to additional degradation mechanisms, such as proteasomal degradation (Sriram et al., 2011).
Another peptide produced from the cleavage of POMC is adrenocorticotropic hormone (ACTH), which can be further cleaved to form α-MSH.
The procaspase-8 dimer is further stabilized by cleavage between the large and small subunits [ 7, 33].
TGF- β is further activated by cleavage of its binding protein, latent activating protein (LAP), by MMP-2 and MMP-9 (Yu and Stamenkovic 2000).
Removal of the signal sequence generates the 67-residue prohormone, proIAPP, which is further processed by cleavage at two conserved dibasic sites by the same prohormone convertases that process proinsulin.
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