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The first two amino acids (Arg143 and Gly144) of the RNP1 motif of U1-70K have been shown to be fundamental for binding to U1 snRNA (Surowy, 1989).
According to the predictions, the truncated form shares most of the potential residues involved in substrate binding, but has lost the Phe513 residue of the C-domain, indicating that this residue may be fundamental for binding of xylobiose in subsite −1, and that naturally occurring single-domain enzymes has solved this by using a different set-up of substrate-interacting residues.
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In fact, the electrostatic interactions are fundamental for binding with ions, plasma proteins and, subsequently, cells and tissues.
Generation of tBid is fundamental for binding Bax, which insert into the mitochondrial membrane bilayer and determine apoptotic cell death.
ALPL has been shown to be fundamental for mineralization.
Pi binding is fundamental for ATP synthesis by ATP synthase.
We identified a fusion protein of Mx2 containing the N-terminal 83-aa and the complete BSE (N-GF), which was fundamental for the detection of Mx2-CA binding in vitro.
"Work is fundamental for dignity.
"Family is fundamental for us," said Ms. Allen.
However, their role is fundamental for herding.
The first is fundamental for successive configurations.
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