We previously determined that CD44v7-10 was functionally significant for PCa invasion[ 3] and is increased by calcitonin, a pro-growth paracrine hormone[ 14].
It was also shown that POLA2+1747 GG/GA is functionally significant for protein localization via green fluorescent protein (GFP -tagging and confocal laser scanninGFP -tagging andlysis.
Such conservation suggests that each SS is functionally significant for synthesis of granular starch as opposed to water-soluble glycogen, presumably through its influence on the architectural structure of amylopectin.
Whether the specific enrichment of mitochondria at the cleavage furrow is functionally significant for mitochondrial inheritance or cell division is unknown and will be the focus of future studies.
Being the sole output neuron of the cerebellar cortex, the firing patterns of Purkinje neurons are functionally significant for motor co-ordination and motor learning (Thach, 1968; Medina, 2011; Yang and Lisberger, 2014; Hewitt et al., 2015).
But this question remains unanswered, and the possibility that the number of cells produced is not large enough to be functionally significant has serious implications for popular claims, such as that exercise can improve memory, and also for the new view of the brain that has been adopted so quickly.
This malleable tethering of the JM to the C-helix is likely to be functionally significant, as this may provide a framework for the JM and the activating monomer to dynamically control C-helix movement [11], [12].
The absolute negative value at 200 nm implies a degree of intrinsic disorder exists in the structure [65], [70], which may be functionally significant due to the different roles suggested for the propeptide region of the myostatin precursor, requiring flexibility in the N-terminal domain.
Though we cannot exclude indirect binding, the interaction of UNC-45 and UFD-2, two non-sarcomeric proteins, could be functionally significant.
