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Thereby, rs10336, rs3921, and rs4619915 polymorphisms could be functionally responsible for the observed effect or could just be polymorphisms in high LD with the causal mutation.
In the light of this information, impaired resolution of inflammation is likely to be functionally responsible for the exacerbation of airway remodelling.
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DNA markers detecting polymorphisms in genes that are functionally responsible for changes in phenotypes can be called functional markers [ 27, 45].
Glycoproteins with aberrant glycosylation that are functionally responsible for cancer progression are more likely to be used as cancer biomarkers.
Future studies will be necessary to determine which genes are functionally responsible for the initiation of regeneration.
In order to quantitatively assess whether cilia are functionally responsible for correct LR patterning, we performed a meta-analysis of the cilia literature and collected reported values for cilia number, cilia length, and ciliary flow rate in normal and LR-compromised conditions.
The BDNF-associated gene is also functionally responsible for type 2 diabetic nephropathy, as determined through previously reported microarray analyses [ 31].
This study was designed to locate the opiate receptors functionally responsible for this inhibition.
Outside these conserved domains, cuticular proteins share hydrophobic regions dominated by tetrapeptide repeats (A-A-P-A/V), which are presumed to be functionally important [ 55, 56] and are responsible for the high percentage of indels found in these proteins.
Another explanation for the strong inhibition of PGE2 production, in contrast to the partial reduction of mPGES-1 and COX-2 expression, may be a synergistic effect of the concerted inhibition of these two enzymes, since they are functionally coupled and responsible for the coordinated PGE2 synthesis [ 79].
If the novel transcribed regions identified in this study are functionally important and responsible for the maintenance of empty chromosomes in the S. noctiflora mitochondrial genome, we would predict that chromosomes containing these elements are more likely to be conserved among S. noctiflora populations.
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