Sentence examples for be functionally required for from inspiring English sources

Genes whose disruption confers the sensitivity to H2O2 would be functionally required for growth under the H2O2 stress condition.

These findings suggest that the estrogen-induced association of Sp1 and Sp4 at the GC-box may be functionally required for estrogen-mediated transactivation of the BRCA1 promoter.

A different class of noncoding RNAs termed Y RNAs has been shown to be functionally required for chromosomal DNA replication in mammalian cell nuclei (Christov et al, 2006).

Furthermore, UTX and JMJD3 were shown to be functionally required for transcriptional activation of lineage-defining T-box transcription factors (including T-bet, Eomes and Tbx5), which represent essential transcriptional regulators in early cell-fate decisions, differentiation and organogenesis.

To analyse whether Rho1 was functionally required for RhoGEF2 function, we reduced the levels of Rho1 via expression of a previously validated RNAi transgene (Rho1 RNAi) (Massarwa et al., 2009; Widmann and Dahmann, 2009; Yan et al., 2009).

A recent RNAi screen identified 3 additional proteins that are functionally required for efficient silencing of the IVS3 splice site.

YAP/TAZ signaling is functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and nuclear YAP/TAZ localization has been associated with response to increased ECM stiffness in several tissues [47, 48].

Reciprocally, YAP transcriptionally upregulates the Notch ligand genes JAG1 and DLL1 and the core Notch transcription factor RBPJ This bidirectional circuit boosts expression of key stem cell genes, including SOX2, which is functionally required for eRMS spheres.

We next asked whether ADAM10 or ADAM17 - which are the primary sheddases for most ectodomains [29] - were functionally required for GPNMB/OA shedding.

PYCARD has been identified as an adaptor protein for NLRP3 and NLRP1, and it is functionally required for the NAIP5 and NLRC4 inflammasomes [12].

Presumably this interaction occurs via the N-terminal RGD domain in GPNMB/OA, which is functionally required for its ability to adhere to endothelial cells [2].