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If the functional replacement of many RNA modification by salts had indeed occurred, then modified nucleotides remaining in t+rRNA of halophilic organism must serve purposes other than stabilization of RNA architecture, such as decoding, accuracy of translation or other functions that cannot be functionally replaced by the electrostatic interactions provided by the surrounding salts.
Experiments have shown that these two invariant sites can be functionally replaced by other amino acids, but their replacement will lead to new DNA-binding specificities.
This could be explained by the functional redundancy of cytokines, where a single cytokine can be functionally replaced by others.
Subsidiary activator binding sites in the wild-type were found to be required for full activity, but, surprisingly, these sites could not be functionally replaced by strong binding sites.
In contrast, the domain encompassing amino acids 240 to 301 (containing part of the transcriptional activation domain of v-myb) was absolutely required for the response of CNR cells to bFGF and could be functionally replaced by the carboxyl-terminal transcriptional activation domain of the VP16 protein of herpes simplex virus.
This suggests that the D. radiodurans RecA protein is not as unusual as initially believed, but rather is more analogous to polA and uvrA of D. radiodurans, which can be functionally replaced by E. coli orthologs [4], [90], [93], [120].
Similar(36)
In general, psychiatric hospitals were functionally replaced not by community mental health centers, but by jails, prisons, and homeless shelters.
We detected no scavenging activity of raptors on urban beaches, where scavenging birds of prey were functionally replaced by nocturnally foraging, non-native mammals (red fox, Vulpes vulpes) or feral species (cats, dogs) known to threaten beach-dwelling wildlife.
Heart cells may last 50 years, but their subcellular innards are functionally replaced in three days.
Later, it was used as a segment of US Highway 25 (US 25) before that highway was functionally replaced by Interstate 94 (I-94) in the 1960s.
In the forebrain, CLOCK is functionally replaced by another bHLH-PAS factor, NPAS2 [19].
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