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Exact(23)
For this reason, we focused our analysis also on other centrality metrics (i.e., betweenness, closeness, radiality, stress): in biological terms, these may be interpreted as the probability of a protein to be functionally relevant for other proteins and its functional ability to connect different cell nodes.
The authors suggest that rather the noisiness itself might play a functional role: high levels of noise might be functionally relevant for the transition from multi- to restricted potency.
It is highly striking to observe that most of these TF and regulatory genes, which are likely to be functionally relevant for Ras-MAPK signaling and/or beta cell function, are overexpressed (Additional file 1: Table S1).
Genes involved in muscle growth, muscle contraction and specific metabolic pathways have been found to be functionally relevant for the early performance evaluation of elite athletic horses.
There are indications that these remote effects can be functionally relevant for behavior [22], [23].
It is interesting to speculate that differences in Pcdh gene regulation may be functionally relevant for hippocampal development.
Similar(37)
Our data indicate that copy number gain may have a functional role in the PHC3 locus too, and that PHC3 upregulation is functionally relevant for cancer cells.
In line with evidence from rodent studies, ripples are functionally relevant for memory consolidation in humans as well24.
Our results demonstrate that the cytotoxicity of induced Alu repeats is functionally relevant for the human adult stem cell aging.
We also demonstrate that HMGCLL1 polymorphism is functionally relevant for CML cell growth and viability, and that HMGCLL1 blockade is cytotoxic to CML cells.
For example, for malignant tumours it is has become relevant to know which of the genetic alterations is functionally relevant for abnormal cell proliferation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com