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Of the mutants that exhibited a sporulation defect, several seemed to be functionally related in mRNA export, Cdc48 function, or ESCRTIII complex.
This result suggested that expression of stathmin and p53MUT could be functionally related in HG-EOC.
These results suggested that both tco89Δ and H3K37A might be functionally related in their effects on cell-cycle regulation.
As DNMT3L interacts with and promotes de novo DNA methylation activity of DNMT3B (Suetake et al, 2004), the role of these two genes might be functionally related in tumorigenesis of teratocarcinoma.
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A pair of genes might be functionally related if they operate in the same complex, pathway or transcriptional module.
It has been observed that phylogenetically co-related proteins are functionally related in many cases [ 41].
These findings suggest that these hyperactivation-ralated genes and sAC are functionally related in sperm hyperactivation and sAC falls into an expanding group of sperm proteins that appear to be promising targets for the development of male contraceptives.
The evolutionarily conserved Ccr4-Not and Bur1/2 kinase complexes are functionally related in Saccharomyces cerevisiae.
For some diseases, it has been shown that disease candidate genes are functionally related in the form of protein complexes or biological pathways [11].
LTPs, pectinesterases, and glycoside hydrolases are functionally related in membrane biogenesis and cell wall extension [ 35- 37].
Given that UGO1, MGM1 and FZO1 are functionally related in mitochondrial fusion we reanalyzed their behavior in response to pQ56-transformation (Additional file 15).
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