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Still, these findings indicate that MIRO2 may be functionally redundant to MIRO1 during embryo development.
The expression data presented here shows that during pollen development and germination, MIRO2 has higher expression levels compared to MIRO1 and clearly suggests that MIRO2 could be functionally redundant to MIRO1.
Interestingly, DLX6-AS1 possesses the highest correlation (Pearson's correlation coefficient = 0.87) with DLX2, which has been shown to be functionally redundant to DLX1.
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We wished to know whether there are any CNAs that cooperate in ovarian tumorigenesis, or that are functionally redundant to each other, for example if they act in the same pathway.
Our data shows that c-Myc binds three out of the four reprogramming factors (Oct4, Sox2, Mycn) and one other another gene, Klf5, which is functionally redundant to the reprogramming factor Klf4 [18].
Despite these differences, all the isoforms are functionally redundant to some extent in ecdysone-induced developmental processes [ 11].
These four isoforms are functionally redundant to some degree as expression of at least one family member is essential for growth [ 18].
Nevertheless, JAZ members are functionally redundant to some extent [ 17- 19] and the diversity in their structures suggests specific roles for some of them.
Possibility exists that TNKS1 and TNKS2 are functionally redundant to each other, which may explain the uncompromised overall glucose intake in TNKS1-deficient mice.
Since both PKA and Sch9 can phosphorylate Maf1 at similar amino acids in vitro [ 35, 37], an interesting question had been whether PKA was functionally redundant to Sch9.
Our work thus demonstrates that the auditory MET machinery undergoes a molecular maturation process, switching from a developmental form in which the Pcdh15 isoforms are functionally redundant to a fully mature form in which Pcdh15-CD2 is critical.
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