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Moreover, mDC and pDC appear to be functionally linked in both species as intensive cross-talk between the DC subsets is essential for CpG-induced immune activation in both mice and man [16], [17].
In fact, VEGF-A is highly expressed in many malignant tumors, including lung cancer [30], [31], [32], and the expression of VEGF-A is associated with poor prognosis [33], [34] and the presence of lymph node metastasis [35], raising the possibility that the biological roles of FLJ10540 and VEGF-A might be functionally linked in lung adenocarcinoma.
These data suggest that JMJD6 and TGF-β2 may be functionally linked in cell-cycle regulation and in development.
What is also clear is that this pathway, and those regulated by the Class IV PI3K-related enzymes such as ATM, can also interact with BRCA1 and p53, suggesting that all these proteins may be functionally linked in the maintenance of normal breast tissue status.
DNA translocation and TFP biogenesis are known to be functionally linked in Gram-negative bacteria [ 4], and TFP are essential for high levels of DNA transformation in most organisms [ 5], although the mechanistic details of both processes remain to be elucidated.
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Impairments in LV diastolic function and forearm flow-mediated dilatation were functionally linked in diabetic patients (19).
It has been proposed that pyrin and PSTPIP1 are functionally linked in an unknown pathway that is connected to the innate immune system [5], [16].
In studies here, to demonstrate that the insulin pathway and HMGCR are functionally linked in Drosophila, we first show that hmgcr mutation also disrupts the sexual dimorphism.
A provisional conclusion, for future exploration, is that the nc-rRNA and rRNA are functionally linked in the majority of these lung cancer cells.
RNA processing reactions have been extensively studied using biochemical systems; however, these are functionally linked in living cells providing increased efficiency and regulatory potential for gene expression [3].
Our data collectively might suggest that the two proteins are functionally linked in renal epithelial cells to protect the renal tubule from apoptosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com