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There are two highly related isoforms, eIF4AI and eIF4AII (85 90% sequence identity) which are thought to be functionally interchangeable for translation initiation [12], [13].
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Although the competing engines have to be functionally interchangeable, each will incorporate proprietary technologies and processes that preclude some aspects of life-cycle support from being competed at all.
Flavodoxins can be functionally interchangeable with ferredoxins and may be used as an alternative redox partner [12].
The N-terminal tails of histones H3 and H4 have been shown to be functionally interchangeable [ 51, 52].
Like eIF4G, two active isoforms of eIF4A exist in mammalian cells (eIF4AI and eIF4AII) and these appear to be functionally interchangeable.
That is, genetic redundancy, in the sense that at least some SRF genes are functionally interchangeable, is likely not a major cause for the lack of phenotypes in srf mutants.
PDF2 and ATML1 are functionally interchangeable and work together to regulate the molecular pathway required for the differentiation of the protodermal cell layer in the embryo [ 10, 28, 34, 35].
Specifically, we asked: (i) if the helicase activity of eIF4AI is required for translation (or is its ATPase activity sufficient); (ii) if eIF4A:einteractionctisn is essential for translation, and (iii) whether eIF4AI and eIF4AII are functionally interchangeable.
Given that Cdc15's and Imp2's SH3 domains are functionally interchangeable (Ren et al., 2015) and Cdc15's F-BAR can substitute for Imp2's, the central region of these two proteins must specify important functional distinctions.
At one heavy-equipment manufacturer, managers estimated that hundreds of parts were functionally interchangeable.
Johnson, A. W. Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and Cytoplasm, Respectively.
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