Sentence examples for be functionally inactivated in from inspiring English sources
Because the nuclear localization of BAP1 is important for its tumor suppressor function, BAP1 may be functionally inactivated in a substantial portion of ESCC.
In our analysis, we concluded that Rb may be functionally inactivated in UM as a result of cyclin/cdk complex phosphorylation that blocks its tumor suppressor activity.
The p53 tumor suppressor gene is mutated in about half of human cancers, but the p53 pathway is thought to be functionally inactivated in the vast majority of cancer.
However, the nucleosome binding subunit CBX8, that anchors the complex to methylated histone H3K27 through its chromo domain [38], was downregulated suggesting that also the PRC1 complex may be functionally inactivated in EBNA-1 expressing cells.
The tumour suppressor PP2A has been shown to be functionally inactivated in several types of human cancer through different contributing mechanisms, including the hyperphosphorylation of its catalytic subunit (Saydam et al, 2003; Cristobal et al, 2011).
Therefore, BAP1 may be functionally inactivated in these cases with alterations of UBE2O or other genes involved in BAP1 ubiquitination, specifically in nuclear BAP1-negative but cytosolic positive tumors.
This includes the retinoblastoma protein (pRB), a tumor suppressor that is functionally inactivated in all human tumors, and two related proteins, p107 and p130.
The activity of the E2Fs is regulated by their interaction with a second family of proteins called the pocket proteins, which includes the retinoblastoma protein, a tumor suppressor that is functionally inactivated in all human tumors.
The retinoblastoma tumor suppressor (RB) is a regulator of the cell cycle that is functionally inactivated in a variety of human cancers [6], [7], [8].
This locus is functionally inactivated in a significant percentage of sporadic melanoma [24] and encodes two independent protein products, p16INK4a and p14 [53], [53].
We obtained Bmpr1 DKO mice in which both BMPR1A and BMPR1B have been functionally inactivated in the neural tube by E10.5 using the Bcre-32 transgenic allele.
