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We identified the PrDs in the viral surface proteins that are involved in the direct contact and fusion of viruses with the host cell membrane, indicating that PrDs may be functionally implicated in these processes as well.
The latter finding suggests that ERCC6 may be functionally implicated in the aetiology of AMD.
This is consistent with our previous observations that GPNMB/OA is also overexpressed in human breast tumors, and suggests that GPNMB/OA may be functionally implicated in regulating tumor growth in addition to promoting invasion and metastasis [18], [19].
However, CA IX is not just a surrogate marker of tumour hypoxia, but appears to be functionally implicated in tumorigenesis via its capacity to modulate cell adhesion and acidify the microenvironment of hypoxic cells (Svastova et al, 2003, 2004).
TERE1 is closely linked to DISP3 (1p36.22) that encodes multi-span transmembrane proteins implicated in the processing of lipid-enhanced secreted proteins (Katoh and Katoh, 2005), a process we have reported to be functionally implicated in aggressive prostate cancer (Forootan et al, 2009).
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Identifying targets of LDEs is critical to understand how such modifications are functionally implicated in oxidative-stress associated diseases.
Background & Aims: Carbonic anhydrase (CA) IX is a highly active enzyme with adhesion capacity that is functionally implicated in acid-base balance and intercellular communication.
Interestingly, the planarian EGFRs and ligand show a broad spectrum of expression patterns23,25,30 and are functionally implicated in the regeneration and homeostasis of different organs and cell types, such as the pharynx, the excretory and nervous systems, and the eye pigment cells23,25.
In addition to FliS, TP0046 and TP0048 have also been functionally implicated in bacterial motility and the ortholog of TP0945 shows a motility phenotype in E. coli [14].
sLex not only is a marker for cancer but also is functionally implicated in the malignant behaviour of cancer cells [14], [15].
Septins belong to the GTPase superclass of proteins and have been functionally implicated in cytokinesis and the maintenance of cellular morphology.
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