Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation.
Macrophages are considered to be functionally heterogeneous cells with different phenotypes representing distinct sublineages [1],[2].
The population of necklace glomeruli may be functionally heterogeneous.
Accumulating studies show that macrophages are functionally heterogeneous and closely involved in the initiation and the resolution of intestinal inflammation by being activated into either pro-inflammatory M1 or anti-inflammatory M2 macrophages.
Many of these families are functionally heterogeneous, containing members that differ in substrate specificities as well as sites and modes of substrate cleavage.
We also note that while CD34+ cells are functionally heterogeneous themselves [42], purification reduces cell-specific variability in cytosine methylation that could otherwise mask (or artificially create) IUGR-related changes.
Already the anatomy suggests that in the adult brain NSCs are functionally heterogeneous and efforts so far to map different hormonal peptides to the Drosophila NSCs has certainly underscored the complexity of the NSC systems in the brain.
Some studies suggested that human FOXP3+ cells (in contrast to mouse FoxP3+ Treg) are functionally heterogeneous [41] and that transient expression of FOXP3 on activated T cells does not correlate with suppressive function [42].
The function of APBs is unknown and it is possible that they are functionally heterogeneous.
However, the insular cortex is functionally heterogeneous, consisting of multiple distinct subdivisions and the FCs between these subdivisions and other pain processing regions remain largely unknown.
