PYK2 is functionally distinct as it is involved in signalling pathways initiated by extracellular signals that elevate intracellular calcium concentration and by stressful stimuli (reviews in [ 25, 26]).
The cathepsin B forms that appear as frequent in juveniles are quite distinct to the cathepsin B transcripts found in the adult stage dataset (Additional Files 7 and 8), suggesting that they might also be functionally distinct; cathepsin B1 functions as a digestive enzyme in the juvenile gut [ 62].
Complementary single-nucleotide polymorphisms (SNPs) may not be distributed equally between two DNA strands if the strands are functionally distinct, such as in transcribed genes.
Where the two DNA strands are functionally distinct (such as in transcribed sequences), the two complementary substitutions may not occur with equal frequency on each strand[ 1], due to transcription-related mutation/repair mechanisms or selective pressure from functional effects on mRNA.
My laboratory (Grün et al. 2002) and another laboratory (Moore et al. 2002) have shown that BXR and SXR (also known as PXR) are functionally distinct and that BXRs do not function as xenobiotic receptors.
It may also be concluded from our results that the gene annotated as second Sti1/HOP orthologue, HOP2, is functionally distinct from the Sti1 gene as its presence is insufficient to overcome a lack of Sti1.
However, PGP-3 is functionally distinct from CFTR in that it functions as an ATP-dependent drug transporter and not as a cAMP-activated Cl− channel (Lincke et al., 1993; Broeks et al., 1995).
New information, i.e. an element highlighted by the speaker as newsworthy, is functionally distinct from referentially new information, i.e. not previously mentioned, because reference is typically realised by deictic markers of definite and indefinite reference, while information structure in spoken English is realised by intonation.
The main point of this paper is that ATP-dependent chromatin assembly is functionally distinct from ATP-dependent chromatin remodeling, as in the title.
Regulatory T (Treg) cells are functionally distinct from the other Th subsets as they suppress and possibly re-direct immune responses.
