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In the elderly, increased mortality has been observed in patients with age-related muscle loss, so called sarcopenia, and in those considered to be functionally disabled as a result of clinical frailty [ 14].
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However, even in the absence of mutation, there is evidence that wild-type p53 may be functionally disabled in Ewing sarcoma as a consequence of the EWS-FLI1 oncogene (Ban et al, 2008; Li et al, 2012).
Persons with moderate to severe functional disability were functionally disabled in either two (2%), three (14%), four (46%) or five (38%) SMAF domains.The prevalence of moderate to severe multidimensional functional disability (32%), varied according to the different SMAF dimensions/domains: it ranges from 7% (ADL) to 86% (IADL), as illustrated in Figure 1.
We will not assume that, or examine whether, individuals with psychometrically-defined "severe" or "profound" intellectual disabilities are functionally disabled in this way.
There is a growing number of young adults with long term health problems who cannot obtain private health insurance and cannot be covered by Medicaid because they are not categorized as being functionally disabled [ 9].
Throughout the continuous caffeine application, SR Ca2+ uptake is functionally disabled since caffeine prevents SR Ca2+ accumulation (25, 26).
These discrepant results could be due to the fact that none of our subjects were functionally disabled even though they were elderly.
It has been estimated that 11% of men and 19% of women over the age of 65 years living in the UK are functionally disabled[ 2].
Spector and Fleishman [ 65] began their study by restricting their sample to those subjects that were functionally disabled in at least one task (4463 to 2977).
Though he uses a walker for balance, he isn't functionally disabled as long as he lives in an elevator building and has someone to run errands.
Our study revealed that RA patients requiring cervical spine surgery have a higher disease activity (as represented by the DAS28-CRP) and are more functionally disabled (as represented by the MHAQ) than control patients.
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