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Significantly the amino acid residue at position 5 (N) proved to be functionally critical for the immunostimulatory properties of VHCDR3, as its substitution by alanine abrogated TNF-α production.
This domain contains all conserved amino acid residues considered to be functionally critical for the enzymatic activity of the staphylococcal nuclease.
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Our data extends this observation by demonstrating that inhibition of Bmi-1 is functionally critical for the miR-128a growth suppressive function.
RAD51 multimerization is functionally critical for HR in cells.
To determine whether AS is functionally critical for myotube hypertrophy, the influence of AS (10 ng/mL) on myotube thickness was examined.
Moreover, none of them were reported to be functionally critical [ 20].
Our study demonstrates that the TWIST1 WR domain is functionally critical to TWIST1-induced cell invasion.
This region is functionally critical due to the splicing of exon 10.
It is unlikely that the generic phospholipids we used to assay binding are the functionally critical ones for Jagged-1, and indeed an earlier genetic study implicated glycosphingolipids in modulating ligand activity in Drosophila (Hamel et al., 2010).
They have to be functionally equivalent campuses.
Here, we also examined if SRM1 contains any critical amino acid residue that is functionally important for homologous recombination.
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