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Most of such motifs may not be functionally conserved in Ph. infestans and Pl.
Thus, dlg5 may be functionally conserved in flies and mammals, as is characteristic of many of the other MAGUK proteins.
For this reason, they may be functionally conserved in natural diversity, as large effect alleles are rapidly purged by selection.
Based the sequence analysis data, we hypothesized that the BdCBF proteins, and related cold signaling pathways as well, would be functionally conserved in Brachypodium.
This E-Syt2 binding site (ESB) was initially mapped on Xenopus PAK1, but was shown to be functionally conserved in human PAK1.
If MAT genes play an important role in the initiation and further steps of sexual reproduction [ 39, 40] they are expected to be functionally conserved in sexual species.
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Of 682 total plant miRNAs, 242 (35.5%) represent functional conserved miRNAs, and 16 (6.6%) of which are functionally conserved in more than 3 abiotic stresses response in different plant species (see Additional file 1).
These findings could reflect the absence of any role for tankyrase in telomere length regulation in mice, in contrast to the function of telomerase, which is functionally conserved in humans and mice.
This analysis suggests that human HKG functions, mostly involving gene expression, are functionally conserved in model organisms such as worm and yeast, while many human TEG-related functions were acquired after the divergence between humans and lower organisms.
Mammals are heavily reliant on hearing for a variety of ecologically important roles (Macdonald 2009) and it is likely that evolution has acted primarily to conserve the function of hearing genes, many of which are functionally conserved in tetrapods.
Since all these proteins fulfill diverse functions during cytoskeletal organization, and since signaling processes are functionally conserved in nature, it was hypothesized that SmTK3 might be involved in signal transduction cascades affecting cell architecture in S. mansoni, too.
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